The intrauterine and nursing period is a window of susceptibility for development of obesity and intestinal tumorigenesis by a high fat diet in min/+ mice as adults

We studied how obesogenic conditions during various life periods affected obesity and intestinal tumorigenesis in adult c57bl/6j-min (multiple intestinal neoplasia)/+ mice. the mice were given a 10% fat diet throughout life (negative control) or a 45% fat diet in utero,during nursing,during both in utero and nursing,during adult life,or during their whole life-span,and terminated at 11 weeks for tumorigenesis (min/+) or 23 weeks for obesogenic effect (wild-type). body weight at 11 weeks was increased after a 45% fat diet during nursing,during both in utero and nursing,and throughout life,but had normalized at 23 weeks. in the glucose tolerance test,the early exposure to a 45% fat diet in utero,during nursing,or during both in utero and nursing,did not affect blood glucose,whereas a 45% fat diet given to adults or throughout life did. however,a 45% fat diet during nursing or during in utero and nursing increased the number of small intestinal tumors. so did exposures to a 45% fat diet in adult life or throughout life,but without increasing the tumor numbers further. the intrauterine and nursing period is a window of susceptibility for dietary fat-induced obesity and intestinal tumor development. © 2015 ha thi ngo et al.