Predictors of Insulin Resistance in Children versus Adolescents with Obesity

Introduction. obesity is a risk factor to develop metabolic syndrome (mets) and type 2 diabetes mellitus (t2dm). insulin resistance (ir) plays a major part in both. with increasing incidence of childhood obesity,this retrospective study aimed to identify predictors of ir in children/adolescents with obesity to optimize screening for ir. method. patients aged ≥ 2-≤ 18 years with obesity (bmi-sds > 2.3) were included. ir was defined as homa-ir ≥ 3.4,and mets if ≥3 of the following criteria were present: waist circumference and blood pressure ≥ 95th age percentile,triglycerides ≥ 1.7 mmol/l,hdl < 1.03 mmol/l,and fasting plasma glucose ≥ 5.6 mmol/l. results. in total,777 patients were included. of the 306 children,51,38,and 0 were diagnosed with ir,mets,and t2dm,respectively. of the 471 adolescents,223,95,and 0 were diagnosed with ir,mets,and t2dm,respectively. in the multivariable regression model,bmi-sds,preterm birth,and tanner stage were associated with ir in children (6.3 (95% ci 1.3-31.1),5.4 (95% ci 1.4-20.5),2.2 (95% ci 1.0-4.8)),and bmi-sds and waist circumference in adolescents (4.0 (95% ci 1.7-9.2),3.7 (95% ci 1.5-9.4)). conclusion. different ir predictors were observed in children/adolescents with obesity. these predictors can be used to optimize screening for ir in pediatric populations. © 2017 yvette e. lentferink et al.