Vitamin D status is not associated with outcomes of experimentally-induced muscle weakness and pain in young,healthy volunteers

Vitamin d receptors have been identified in skeletal muscle; and symptoms of vitamin d deficiency include muscle weakness and pain. moreover,increased serum 25-hydroxyvitamin d (25(oh)d) concentrations have been associated with improved muscle function. to further clarify the importance of vitamin d to muscle,we examined the association between vitamin d status and exercise-induced muscle pain and weakness in healthy people. muscle damage to the elbow flexors was induced with eccentric exercise (ee) in 48 individuals (22.5 ± 3.2 yrs). muscle pain ratings following unloaded movement and peak isometric force (if) were collected before ee and for 4 days post-ee. linear regression was used to determine if serum 25(oh)d was a predictor of any outcome. in males,r 2 -values from 0.48 to 1.00. r 2 for if ranged from 0 to 0.02 and p -values from 0.48 to 1.00. in females,r 2 for pain ratings ranged from 0.01 to 0.11 and p -values from 0.14 to 0.59. r 2 for if ranged from 0 to 0.04 and p -values from 0.41 to 0.90. in conclusion,vitamin d status did not predict muscle pain or strength after ee-induced muscle damage in young healthy men and women. © 2010 susan m. ring et al.