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Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated fatty acid levels and MRI measures of cardiovascular structure and function: the multiethnic study of atherosclerosis
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نویسنده
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anderson j.s. ,nettleton j.a. ,hundley w.g. ,tsai m.y. ,steffen l.m. ,lemaitre r.n. ,siscovick d. ,lima j. ,prince m.r. ,herrington d.
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منبع
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journal of nutrition and metabolism - 2011 - دوره : 2011 - شماره : 0
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چکیده
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Background. the association between plasma omega-6 fatty acids and cardiovascular disease (cvd) is unclear,and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. methods. associations of plasma phospholipid fatty acid levels (arachidonic acid,linoleic acid,eicosapentaenoic acid,docosahexaenoic acid (dha),and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (lv) mass,lv volume,ejection fraction,stroke volume,and aortic distensibility were investigated in 1,274 adults. results. results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. stratification by gender revealed a positive association between dha and lv mass in women (β = 1.89,p = 0.02; p interaction = 0.003) and a trend for a positive association between dha and ejection fraction in men (β = 0.009,p = 0.05; p interaction = 0.03). conclusion. additional research is warranted to clarify the effects of plasma dha on cardiac structure and function in women versus men. © 2011 jennifer s. anderson et al.
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آدرس
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division of cardiology,deparment of internal medicine,wake forest university,winston-salem, United States, division of epidemiology,human genetics and environmental sciences,university of texas health sciences center at houston,houston, United States, division of cardiology,deparment of internal medicine,wake forest university,winston-salem, United States, division of epidemiology and community health,university of minnesota,minneapolis, United States, division of epidemiology and community health,university of minnesota,minneapolis, United States, department of medicine and epidemiology,university of washington,seattle, United States, department of medicine and epidemiology,university of washington,seattle, United States, division of cardiology,department of medicine,johns hopkins university,baltimore, United States, department of radiology,columbia college of physicians and surgeons,new york, United States, division of cardiology,deparment of internal medicine,wake forest university,winston-salem, United States
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Authors
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