Combinational effects of prebiotics and soybean against azoxymethane-induced colon cancer in vivo

Prebiotic fructans are nondigestible carbohydrates with numerous health benefits. soybean is a rich source of phytonutrients such as isoflavones. the objective of this study was to evaluate the chemopreventive effects of prebiotics (synergy1) and soybean meal (sm) at 5% and 10% levels alone and in combination on azoxymethane- (aom-) induced colon carcinogenesis. after one wk of acclimatization,fisher 344 male rats (n=90) were randomly assigned to 9 groups (n=10). control rats (c) were fed ain-93g/m. two s/c injections of aom were administered to rats at 7 and 8 wk of age at 16 mg/kg body weight. rats were killed by co2 asphyxiation at 45 wk. tumor incidence (%) in treatment groups ranged from 40 to 75 compared to 100 in c. results indicate that feeding prebiotics and soybean in combination significantly reduced incidence of aom-induced colon tumors with implications for food industry in the food-product development. © 2011 v. p. gourineni et al.