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Distinct effects of calorie restriction and resveratrol on diet-induced obesity and fatty liver formation
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نویسنده
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tauriainen e. ,luostarinen m. ,martonen e. ,finckenberg p. ,kovalainen m. ,huotari a. ,herzig k.-h. ,lecklin a. ,mervaala e.
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منبع
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journal of nutrition and metabolism - 2011 - دوره : 2011 - شماره : 0
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چکیده
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The potential of resveratrol to mimic beneficial effects of calorie restriction (cr) was investigated. we compared the effects of both cr (70% of ad libitum energy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in c57bl/6j mice,and we examined their effects on calorimetry,metabolic performance,and the expressions of inflammatory genes and sirt proteins. we found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle sirt1 and sirt4 expression while other examined parameter were unaffected by resveratrol. in contrast,cr provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol,and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. cr increased expressions of sirt3 in metabolically important tissues,suggesting that the beneficial effects of cr are mediated,at least in part,via sirt3-dependent pathways. © 2011 eveliina tauriainen et al.
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آدرس
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institute of biomedicine,pharmacology,university of helsinki,biomedicum helsinki,p.o. box 63, Finland, school of pharmacy,pharmacology and toxicology,university of eastern finland,p.o. box 1627, Finland, institute of biomedicine,pharmacology,university of helsinki,biomedicum helsinki,p.o. box 63, Finland, institute of biomedicine,pharmacology,university of helsinki,biomedicum helsinki,p.o. box 63, Finland, school of pharmacy,pharmaceutical technology,university of eastern finland,p.o. box 1627, Finland, school of pharmacy,pharmaceutical technology,university of eastern finland,p.o. box 1627, Finland, institute of biomedicine,physiology,university of oulu,p.o. box 5000,90014 oulu,finland,biocenter oulu,university of oulu,p.o. box 5000,90014 oulu,finland,department of psychiatry,kuopio university hospital,p.o. box 1777, Finland, school of pharmacy,pharmacology and toxicology,university of eastern finland,p.o. box 1627, Finland, institute of biomedicine,pharmacology,university of helsinki,biomedicum helsinki,p.o. box 63, Finland
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Authors
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