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Inflammatory Markers Are Positively Associated with Serum trans -Fatty Acids in an Adult American Population
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نویسنده
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mazidi m. ,gao h.-k. ,kengne a.p.
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منبع
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journal of nutrition and metabolism - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Background and aim. the relationship between serum trans-fatty acids (tfas) and systemic inflammation markers is unclear. we investigated the association of serum tfas with high sensitivity c-reactive protein (hs-crp) and fibrinogen in adult americans. methods. the 1999 to 2000 national health and nutrition examination survey (nhanes) participants with measured data on hs-crp and fibrinogen were included. tfas were measured via capillary gas chromatography and mass spectrometry using negative chemical ionization. analysis of covariance and multivariable-adjusted linear regression models were used to investigate the associations between these parameters,accounting for the survey design. results. of the 5446 eligible participants,46.8% (n=2550) were men. the mean age was 47.1 years overall: 47.8 years in men and 46.5 years in women (p=0.085). after adjustment for age and sex,mean serum tfas rose with the increasing quarters of hs-crp and fibrinogen (both p<0.001). in linear regression models adjusted for age,sex,race,education,marital status,body mass index,and smoking,serum tfas were an independent predictor of plasma hs-crp and fibrinogen levels. conclusion. a high level of tfas appears to be a contributor to an unfavourable inflammatory profile. because serum tfas concentrations are affected by dietary tfa intake,these data suggest a possible contribution of tfas intake modulation in the prevention of inflammation-related chronic diseases. © 2017 mohsen mazidi et al.
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آدرس
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key state laboratory of molecular developmental biology,institute of genetics and developmental biology,chinese academy of sciences,chaoyang,beijing,china,institute of genetics and developmental biology,international college,university of chinese academy of sciences (ic-ucas),west beichen road,chaoyang, China, department of general surgery,general hospital of chinese people's armed police forces,beijing, China, non-communicable disease research unit,south african medical research council and university of cape town,cape town, South Africa
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Authors
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