Inflammatory Markers Are Positively Associated with Serum trans -Fatty Acids in an Adult American Population

Background and aim. the relationship between serum trans-fatty acids (tfas) and systemic inflammation markers is unclear. we investigated the association of serum tfas with high sensitivity c-reactive protein (hs-crp) and fibrinogen in adult americans. methods. the 1999 to 2000 national health and nutrition examination survey (nhanes) participants with measured data on hs-crp and fibrinogen were included. tfas were measured via capillary gas chromatography and mass spectrometry using negative chemical ionization. analysis of covariance and multivariable-adjusted linear regression models were used to investigate the associations between these parameters,accounting for the survey design. results. of the 5446 eligible participants,46.8% (n=2550) were men. the mean age was 47.1 years overall: 47.8 years in men and 46.5 years in women (p=0.085). after adjustment for age and sex,mean serum tfas rose with the increasing quarters of hs-crp and fibrinogen (both p<0.001). in linear regression models adjusted for age,sex,race,education,marital status,body mass index,and smoking,serum tfas were an independent predictor of plasma hs-crp and fibrinogen levels. conclusion. a high level of tfas appears to be a contributor to an unfavourable inflammatory profile. because serum tfas concentrations are affected by dietary tfa intake,these data suggest a possible contribution of tfas intake modulation in the prevention of inflammation-related chronic diseases. © 2017 mohsen mazidi et al.