Serum paraoxonase (Arylesterase) activity in chronic renal failure

Background: mortality rates are higher among patients with chronic renal failure with a good proportion of this excess burden being attributable to cardiovascular disease. this excess risk is not entirely explained by elevated traditional risk factors. among the non-traditional risk factors,serum paraoxonase (arylesterase) activity is an important one. materials and methods: it was a case-control study which included total 127 subjects,44 were non-dialysis ckd patients,33 heamodialysis dependent patients and 50 healthy controls. hdl-c,apo-a and serum paraoxonase (arylesterase) activity was estimated and compared with normal control population. results: serum arylesterase activity,a measure of pon was significantly lower in crf (on conservative management and on hemodialysis) compared to controls. conclusion: measurement of anti oxidant capacity of hdl-c may improve the predictive accuracy of atherosclerotic coronary artery disease,providing new strategies for the prevention and treatment of accelerated atherosclerosis in chronic renal failure.