A clinical study and short term outcome of the patients presented with thyroiditis

Thyroiditis-inflammation of thyroid gland includes a group of individual disorders having many different clinical presentations,aetiopathogenesis and histology. sometimes they are overlapping on their presentations. objectives: to see the clinical biochemical profile and to observe a short term outcome of the patients presented with different types of thyroiditis. materials & methods: 50 cases with clinical suspicion of thyroiditis were randomly selected. clinical history,physical examination and serum t3,t4,tsh was done in every patient and fnac of thyroid gland & tmab (thyroid microsomal antibody) was estimated in some. they were followed up at three monthly intervals with the measurement of tsh. results: cases were subdivided in to 3 groups. among them subacute thyroiditis were 19 (38%),26 (52%) were hashimoto's thyroiditis and 5(10%) were silent thyroiditis. the subacute group presented with features of hyperthyroidism,negligible raiu (radioactive iodine uptake) and fnac (fine needle aspiration cytology) showed granulomatous thyroiditis. during follow up (57%) became hypothyroid at 3 months,(26%) euthyroid and (15%) in thyrotoxic state. after 9 months (87%) was hypothyroid and (5.26%) thyrotoxic. at 12 months (94%) was euthyroid and one thyrotoxic. hashimoto's group presented in hypothyroid state,raiu test were variable. fnac showed lymphocytic infiltration in all patients. they were found 100% hypothyroid after 1 year. silent thyroiditis group were in hyperthyroid state with negligible raiu. after 12 month (60%) became euthyroid and (40%) remain hypothyroid. conclusion: thyroiditis has both thyrotoxic and hypothyroid phase but they are self limiting. so before giving specific therapy,thyroiditis must be excluded.