Lipid abnormalities in the natural history of diabetes

Objective: to explore lipid abnormalities in normoglycemic first-degree diabetic relatives (fdrs) and prediabetic and diabetic subjects in the natural history of diabetes. research design and methods: thirty six impaired fasting glucose (ifg),61 isolated impaired glucose tolerance (i-igt),64 combined ifg-igt,73 diabetic,and 32 fdrs along with 57 normoglycemic healthy controls without family history of diabetes in 1st degree relatives,were selected purposively following 2003 ada cut-off values and 2006 who/idf grouping. anthropometry and blood pressure of the subjects were taken. fasting and 2-h plasma glucose and hba1c were measured. fasting plasma triglyceride,total cholesterol and hdl cholesterol were measured by enzymatic colorimetric method. results: serum triglyceride was higher in ifg,i-igt,ifg-igt,diabetic and fdrs compared to control [145 (59- 307),128 (66-584),166 (68-764),161 (69-750) and 130 (81-281) vs. 108 (47-219) mg/dl,p<0.01,p<0.01,p<0.001,p<0.001 and p<0.05]. total cholesterol was raised in ifg-igt and diabetes compared to control [185 (105-310),185 (123-326) vs. 171 (101-235) mg/dl,p<0.05] and fdrs. but hdl did not differ among the groups. prevalence of metabolic syndrome was higher in ifg,i-igt,ifg-igt and diabetes and fdrs than control [55%,38%,57%,58% and 36% vs. 15%,p<0.001,p<0.01,p<0.001,p<0.001 and p<0.05] and also in ifgigt and diabetic compared to i-igt and fdrs (p<0.05). conclusions: higher prevalence of metabolic syndrome and raised serum triglyceride is seen among diabetic,prediabetic and 1st degree diabetic-relatives. total cholesterol and non-hdl cholesterol is raised only in ifg-igt and diabetes,the more decompensated glycemic states. © 2015 bangladesh society of medicine. all rights reserved.