Identification of Rh alloantibody in thalassaemia patients

Summary: thalassaemiais a congenital hemolytic disorder caused by partial or complete deficiency of α or β globin chain synthesis. the disease is treated by lifelong red cell transfusion. so they are at high risk of developing allo-antibodies,resulting difficult to obtain compatible blood,results in,haemolysis & occasionally life threatening events. objectives: to find out the frequency of rhesus alloantibodies among the thalassaemic patients. methods: this cross sectional study was done in the department of transfusion medicine in bangabandhu sheikh mujib medical university from 01-07-2010 to 03-07-2011. sample size was 100 and the data was collected by face to face interview. purposive sampling method was applied using inclusion & exclusion criteria. statically analysis of the result was obtained by using window based computer software devised with statistical packages for social sciences (spss-15) (spss inc,chicago,il,usa). result: in the present study all respondent were rh d-positive. out of 100 respondents 2 (2.0%) had positive direct coomb’sand 6 (6.0%) had positive indirect coomd’s test. out of 6 respondent with rhesus all-antibody,4 (66.7%) had anti e antibody,1(16.7%) had anti c antibody and 1 (16.7%) had non specific antibody. conclusion: in this study among the 100 respondents of thalassaemic patients who receive regular blood transfusion 6 (6.0%) had developed rhesus allo-antibody among with the most common was anti e antibody 4 (66.7%). such information may enable understanding and prevention of this serious and common complication. © 2016,bangladesh society of medicine. all rights reserved.