Frequency of extended-spectrum beta-lactamase producing organisms causing urinary tract infection and their antibiotic sensitivity pattern

Background: the spectrum of bacteria causing urinary tract infection (uti) and their antibiotic sensitivity pattern is not uniform. escherichia coli and klebsiella sp. are two common organisms responsible for uti through-out the world. the incidence of uti due to infection with extended-spectrum beta-lactamase (esbl) producing organisms are increasing. this study was aimed to describe the frequency of esbl positive organisms causing uti and their antibiotic sensitivity pattern. methods: this cross-sectional study was done in the department of internal medicine,birdem general hospital from january to april,2016. results: total number of patients was 137 with females predominance (m:f ratio 1:3.7).mean age was 60.3 ±11.7 years. most patients (131,95.6%) of the study population were diabetic and glycaemic control was poor (mean hbalc 9.3 ±2.3) in these subjects. common symptoms were fever,vomiting,increased urinary frequency,dysuria,suprapubic pain,and loin pain. neutrophilic leukocytosis was common (94.9%). e. coli (73.7%) was the commonest aetiological agent followed by klebsiella (8.8%),enterococcus (4.4%),citrobacter (3.6%),staphylococcus aureus (3.6%),acinetobacter (2.9%),enterobacter (1.5%),and pseudomonas (1.5%). over half of e. coli and of klebsiella sp. and 100% of enterobacter organisms were esbl positive. imipenem (100%),amikacin,netilmycin,and nitrofurantoin were among the most sensitive antibiotics. conclusion: more than half (71,51.82%) of uti cases were due to esbl positive organisms. imipenem,amikacin,netilmycin,and nitrofurantoin remain the drug of choice. © 2017,bangladesh society of medicine. all rights reserved.