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   Frequency of steatosis in chronic hepatitis C patients in Khyber Pakhtoonkhwa. A clinical and histological study  
   
نویسنده ismail n. ,saeed f. ,hussain h. ,mohammad i. ,naseer f. ,ahmad f.
منبع journal of medical sciences (peshawar) - 2012 - دوره : 20 - شماره : 2 - صفحه:71 -74
چکیده    Objective: to assess steatosis histologically and correlate with body mass index in chronic hepatitis c patients. material and methods: this was a prospective observational study conducted at gastroenterology ward and department of pathology at combined military hospital,peshawar from may 2007 to september 2008. a total of 100 adult patients who were hcv-rna positive fulfilling the pre-requisites for liver biopsy were admitted. liver biopsy was performed and analyzed for necroinflammation,fibrosis and steatosis. steatosis was correlated with bmi by using chi square test. p value of 0.05 was considered as significant. results: fifty-four male and 46 female patients between ages of 13 to 70 years were studied. forty-nine patients (49%) were overweight,16 (16%) were obese. twenty-nine (29%) patients showed grade i steatosis,8(8%) had grade ii and 4 (4%) had grade iii steatosis. strong correlation was found between steatosis and bmi (p-value 0.0001). high bmi is strongly associated with females of >35 years of age,p-value 0.0001. conclusion: steatosis is related to higher bmi and together with necroinflammation results in accelerated disease process in chronic hepatitis c patients. steatosis should always be assessed histologically and included in clinical as well as research analysis.
کلیدواژه Body mass index; Chronic hepatitis C; Necroinflammation; Steatosis
آدرس department of pathology,khyber medical college, Pakistan, department of gastroenterology,military hospital, Pakistan, department of community medicine,khyber medical college, Pakistan, department of pathology,combined military hospital, Pakistan, department of pathology,khyber medical college, Pakistan, department of histopathology,rehman medical college, Pakistan
 
     
   
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