Thyroid dysfunction and its effect on serum lipids

Objectives: to evaluate the incidence of thyroid dysfunction and to investigate the chemical changes in serum lipids under the influence of thyroid dysfunctions. material and methods: this study was conducted in pakistan medical research centre (pmrc),khyber medical college,peshawar,pakistan from january 2011 to august 2014 . blood samples and data were collected from patients attending the institute of radioactive nuclear medicine (irnum) peshawar,pakistan. a total of 600 cases were included in this study out of which 214 were euthyroid,195 and 191 were hyperthyroid and hypothyroid respectively. results: the study subjects are divided into three groups on the basis of hormonal assay for the three parameters i.e. thyroid stimulating hormone (tsh),tri-iodo thyronine (t3),tetra-iodo thyronine (t4). the euthyroid group which includes healthy individuals serves as control. the level of significance chosen as 0.05 and p-values were calculated. conclusion: thyroid dysfunctions are more prevalent in females,total cholesterol (tc),triglyceride (tg) and low density lipo protein cholesterol (ldl-c) levels are positively correlated with hyperthyroidism as well as hypothyroidism,whereas high density lipo protein cholesterol (hdl-c) has no significant relation with thyroid dysfunction. © 2015 khyber medical college. all rights recerved.