Comparison of efficacy of amoxicillin clavulanate and levofloxacin in treatment of acute bacterial sinusitis

Objective: to compare the efficacy of amoxicillin-clavulanate and levofloxacin in the treatment of acute bacterial rhinosinusitis in terms of complete resolution of signs and symptoms. material and methods: this was a randomized control study conducted at the ent department of ayub medical institute (ami),abbottabad and khyber teaching hospital (kth),peshawar from january 2014 to june 2014. a total of 360 patients included in this study were divided in to two groups by non probability technique. group a included 180 patients who received amoxicillin-clavulanate while group b received levofloxacin for 10 days. patients were reevaluated for complete resolution of signs and symptoms on 11th day. results: a total of 360 patients were included with a mean age of 31.16 ± 12.51 years. on the 11th day a total of 317 (88.1%) patients had complete resolution of symptoms and signs including 161 (89.44%) of group a and 156 (86.66%) of group b. there was no statistically significant difference in the frequency of patients and duration of resolution of signs and symptoms between the two groups. conclusion: there was no significant difference in the frequency of patients who had complete resolution of signs and symptoms between the amoxicillin-clavulanate and levofloxacin receiving patients; hence the two drugs were similar in efficacy. © 2015,khyber medical college. all rights reserved.