Clotrimazole,fluconazole,ketoconazole and itraconazole susceptibilities of candida species in vulvovaginitis

Objective: to determine the in vitro susceptibility of vaginal candida species against commonly used azole antifungal agents. material and methods: the isolates were collected and differentiated,which were later on subjected to susceptibility assays. the forty yeast isolates were identified as c.albicans (n=21) c.glabrata (n=13) and c. krusei (n=6). twenty nine (72.5%) isolates were susceptible to clotrimazole,twelve (30%) to ketoconazole,eleven (27.5%) to fluconazole and ten (25%) to itraconazole. results: overall susceptibility order of test agents was clotrimazole>ketoconazole>fluconazole> itraconazole. conclusion: c. albicans was highly susceptible to clotrimazole however c. glabrata showed extreme resistance to almost all test azoles. © 2015,khyber medical college. all rights reserved.