Erythrocyte reological properties in chidren with perthes’ disease and transient synovitis of the hip joint

Objective: to study parameters of aggregation and cytoarchitecture of erythrocytes in children with perthes disease (pd) and transient synovitis of the hip joint(ts). material and methods: this study was conducted at children clinical hospital no 1,ivanovo,russia from 01.11.2001 to 10.02.2006. a total of one hundred and thirty six children (sixteen children from control group),and one hundred and twenty one children diagnosed as pd and ts were examined. determination of aggregation parameters of erythrocytes was carried out by optical method (int. committee for standartization in haematology,1988). the following parameters were estimated: average size of aggregate (asa),parameter of aggregation (pa) and percent of non aggregated erythrocytes (pne). for an estimation of structurally functional properties of membrane of erythrocytes were investigated their cytoarchitecture. patients data was processed statistically using spss version 14. results: increase in asa and pa (p > 0.05) is revealed in ts in comparison with the cg. in pd there was reliable increase in (p < 0.05) contents of asa and pa in i and ii stages (6.2 ± 0.17; 6.1 ± 0.32),(1.7 ± 0.11; 1.6 ± 0.13) accordingly and decrease in percent of pne (58.6 ± 0.11) (p < 0.05) in stage i. analysis of cytoarchitecture of erythrocytes revealed that the main population of erythrocytes were cells of biconcave form (discocytes) and constituted 71.8 ± 2.56 % in cg. reversible forms of erythrocytes (re) composed 18.2 ± 2.07 %,while ie: 9.69 ± 1.76 %. in children with ts discocytes were 72.58 ± 1.66 %,re – 13.84 ± 1.2 %,ie – 12.81 ± 1.28 % (p > 0.05). in patients with of pd,contents of discocytes constituted 73.25 ± 3.01 % and 68.68 ± 4.14 % in stages i and ii respectively,while ie were 15.5 ± 3.57 % in comparison with the cg (p > 0.05). contents of re constituted – 11.25 ± 1.6 %; and 11.37 ± 0.9 % in i and ii stages,p < 0.05 in comparison with the cg. conclusion: rheological characteristics of erythrocytes in i - ii stages of pd are indicated by authentic escalation in aggregation of erythrocytes,reduction in reversible forms and increase in irreversible forms of erythrocytes at ii stage of disease. changes in aggregation characteristics of erythrocytes in children with pd are reliably more expressive,than in patients with ts. © 2017,khyber medical college. all rights reserved.