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Synthesis and biological activity of novel platencin derivatives
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نویسنده
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waalboer d.c.j. ,rutjes f.p.j.t.
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منبع
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journal of mathematical and fundamental sciences - 2011 - دوره : 43 A - شماره : 2 - صفحه:95 -112
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چکیده
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The biological mode of action of platencin,a potential lead molecule for a new class of antibiotics,is detailed. furthermore,enantiopure syntheses of several platencin derivatives are described,of which the core structure can be accessed in two exceedingly simple steps from commercially available starting materials. furthermore,the antibiotic properties of the derivatives was evaluated.
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کلیدواژه
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Antibiotics; Dehydrohomoplatencin; Platencin; Resistance
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آدرس
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radboud university nijmegen, Netherlands, radboud university nijmegen, Netherlands
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Authors
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