Is amelogenesis imperfecta a signal of systemic disorders? A brief review of literatüre

Amelogenesis imperfecta (ai) is a clinically and aetiologically heterogeneous group of inheritable disorders characterised by qualitative or quantitative anomalies of enamel development. ai has a high degree of clinical diversity. affected individuals show either hypoplastic or hypomineralized enamel,while both of these signs is apparent in many cases. the prevalence of ai is reported at 1/700 births in northern sweden and,1/14,000 births in the us. the inheritance patterns include autosomal dominant,autosomal recessive,x-linked dominant or x-linked recessive modes of transmission. several kinds of ai have been reported with x-linked inheritance and the amelogenin genes are found on both x and y chromosomes in humans.