Osteonecrosis related to oral bisphosphonate usage: Case report and review of treatment strategies

Bisphosphonates are a class of agents used to treat osteoclast-mediated bone diseases and many neoplasm types. osteonecrosis of the jaw is a common side effect of bisphosphonate therapy,presenting as exposed and necrotic maxillary and/or mandibular bone. in this report,we present a case of bisphosphonate-related osteonecrosis of the jaw in a patient who received oral alendronate therapy due to osteoporosis. according to the literature,oral bisphosphonate therapy typically causes less severe manifestations than observed in the case presented here. we discuss treatment modalities and the benefits of piezosurgical treatment.