Investigation of periodontal parameters,total antioxidant status and ferritin levels in patients with thalassemia major

Our aim was to investigate periodontal status and total antioxidant status (tas),ferritin levels of serum and gingival crevicular fluid (gcf) in patients with thalassemia major. this study comprised 73 individuals aged between 11 and 16 years,divided into 3 groups; group tms: periodontally healthy 23 patients with thalassemia major,group tmg: 25 patients with gingivitis and thalassemia major,and group c: gingival and systemically healthy 25 individuals. firstly,plaque index (pi),gingival index (gi) and probing depth (pd) data of all individuals in the study were recorded. for serum samples,5 cc blood was taken from the antecubital region of the forearm of every individual. at the same time 4 samples of gcf were taken from the maxillar incisive of every individual,collected by standard periopaper strips. in the comparison of total mouth of the tmg group with the c and tms groups,gi,pi,pd and gcf volume values were higher in the tmg group as expected (p<0.001). in the evaluation of the tms and tmg groups in comparison with the c group,statistically significant differences were determined in the ferritin and tas values of both gcf and serum (p<0.05). no correlation was found in the clinical and biochemical parameters investigated in serum and gcf of the tmg and tms groups (p>0.05). in this study of relatively few patients,the conclusion was reached that thalassemia major was not a direct risk factor in the formation of gingivitis. further studies are needed to investigate the relationship between more severe periodontal disease and thalassemia major in different age groups.