Evaluation of the effect of diacerein on IL-1β and osteocalcin levels in GCF of chronic periodontitis patients: A non-randomized controlled clinical trial

This work has been conducted to evaluate the influence of diacerein (a potent anti-inflammatory drug) both clinically and on 1l-β and osteocalcin levels in gingival crevicular fluid (gcf) in patients with chronic periodontitis. the current experiment included forty-five patients allocated to three equal groups: group i (n=15) included patients with chronic periodontitis who were treated with both scaling and root planing (srp) only; group ii (n=15) involved patients with chronic periodontitis who were treated with srp besides systemic diacerein administered orally and group iii (n=15) healthy volunteers with no periodontal disease. pi (plaque index),gi (gingival index),pd (pocket depth),and cal (clinical attachment level) were recorded. in addition,il-1β and osteocalcin levels in gcf were measured before treatment and after 1 and 2 months' post-treatment. the results revealed the significant change and improvement of all the measured clinical parameters with the reduction of il-1β and osteocalcin levels especially in the group in which diacerein was given. diacerein has a playful therapeutic effect in management of chronic periodontitis.