Autofluoresence and p53 level in saliva examination as an early detection of premalignant lesion in betel chewer at Papua,Indonesia

Chewing betel nut may cause premalignant lesion in the oral cavity (ie: oral lichen planus (olp) and oral submucous fibrosis (osf)). premalignant lesion can be detected by autofluoresence and p53 levels in saliva. oral manifestation in the betel nut chewers are not reported yet at merauke,papua province,indonesia. the aim of this study to know the correlation autofluoresence examination and p53 levels in saliva. the study was correlational cross-sectional with purposive sampling. there are 25 samples (treatment group) betel nut chewer and 5 (control group) non-betel nut chewer examined by autofloresence and p53 levels in saliva by elisa. p53 levels in saliva iii sample groups: non-betel nut chewer (group i control),betel nut chewer with tobacco (group ii treatment) and betel nut chewer without tobacco(group iii treatment) analyzed by kruskal wallis one way anova test obtained p=0.125 (p > 0.05). mann whitney test found p53 levels in saliva between group ii and iii p= 0.15 (p > 0.05),group i and ii p= 0.085 (p > 0.05),group i and iii p= 0.220 (p > 0.05). autofluoresence presented positif result. p53 levels in saliva with autofluoresence examination result analyzed by spearman's test r= 0.120 (p < 0.05). no correlation between the p53 levels in saliva with autofluoresence examination result.