The profile of crosslinked bovine hydroxyapatite gelatin chitosan scaffolds with 0.25% glutaraldehyde

Bone defect is still a major problem in dentistry. in oral cavity,trauma,congenital disorder,periodontitis,and tumor can damage bones. a biomimetic scaffold made of bovine hydroxyapatite (bha),gelatin (gel),and chitosan (k) (bha-gel-k) is on a development in recent researches. this research tends to develop bha-gel-k scaffolds combined with 0.25% glutaraldehyde as cross linking agent. scaffolds' profiles were examined with ftir,porosity size by using sem,and compressive strength by using autograph. the adhesion of bone narrow mesenchymal stem cell (bm-msc) to crosslinked bha-gel-k scaffolds with 0.25% glutaraldehyde were examined by using sem. bha,gel,k and glutaraldehyde components are bonded to each other. these scaffolds have 121.21 μm of porosity and 912.86 + 83.81 kpa of compressive strength value. these scaffolds have good adhesion to bm-msc. the adhesion of scaffolds increases since day 1 to 7. the profile of bha-gel-k scaffolds that crosslinked to 0.25% glutaraldehyde may fulfills a requirement of bone tissue engineering.