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Potential benefits of therapeutic use of β 2-adrenergic receptor agonists in neuroprotection and Parkinson's disease
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نویسنده
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peterson l. ,ismond k.p. ,chapman e. ,flood p.
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منبع
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journal of immunology research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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The β2-adrenergic receptor (β2ar) is a seven-transmembrane (7tm) g-protein coupled receptor that is expressed on cells of the pulmonary,cardiac,skeletal muscle,and immune systems. previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. this review examines the functional dichotomy associated with stimulation of β2ar and microglial cells. as well,recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of parkinson's disease. © 2014 lynda peterson et al.
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آدرس
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theralogics,inc.,1829 e. franklin street,chapel hill, United States, school of dentistry,university of alberta,7020 katz group centre,edmonton, Canada, school of dentistry,university of alberta,7020 katz group centre,edmonton, Canada, school of dentistry,university of alberta,7020 katz group centre,edmonton,ab,canada,north carolina oral health institute,school of dentistry,university of north carolina at chapel hill,manning dr. and columbia street,chapel hill, United States
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Authors
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