Proatherogenic oxidized low-density lipoprotein/β 2-glycoprotein i complexes in arterial and venous disease

Oxldl/β2gpi complexes have been implicated in the initiation and progression of atherosclerosis and associated with disease severity and adverse outcomes. we investigate the significance of anti-oxldl/β2gpi antibodies and oxldl/β2gpi complexes in patients with arterial and idiopathic venous disease. a cohort of 61 arterial disease patients,32 idiopathic venous disease patients,and 53 healthy controls was studied. because statins influence oxldl/β2gpi,these complexes were analyzed on subjects not taking statins. arterial and venous groups expressed higher levels of igg anti-oxldl/β2gpi antibodies than controls without any other significant clinical association. oxldl/β2gpi complexes were significantly elevated in arterial (0.69 u/ml,p=0.004) and venous disease (0.54 u/ml,p=0.025) than controls (0.39 u/ml). among arterial diseases,oxldl/β2gpi was 0.85 u/ml for carotid artery disease,0.72 u/ml for peripheral artery disease,and 0.52 u/ml for abdominal aortic aneurysm. there was a significant association with male gender,age,hypertension,and history of thrombosis. subjects with oxldl/β2gpi above the median (0.25 u/ml) were more likely to have arterial (or 4.5,p=0.004) or venous disease (or 4.1,p=0.008). multivariate regression indicated that males (p=0.021),high cholesterol (p=0.011),and carotid disease (p=0.023) were significant predictors of oxldl/β2gpi. the coexistence of oxldl/β2gpi in arterial and venous disease may suggest a common oxidative mechanism that independently predicts carotid artery disease. © 2014 jeffrey s. berger et al.