|
|
|
|
Alternative expression pattern of malt1-a20-NF- B in patients with rheumatoid arthritis
|
|
|
|
|
|
|
|
نویسنده
|
wang x. ,zhu l. ,liao z. ,zhang f. ,xu l. ,xu y. ,chen s. ,yang l. ,zhou y. ,li y.
|
|
منبع
|
journal of immunology research - 2014 - دوره : 2014 - شماره : 0
|
|
چکیده
|
Rheumatoid arthritis (ra) is an inflammatory autoimmune disorder; abnormal t cell immunity plays a critical role in the development of ra. recently,a20 was identified as a key negative regulator for t cell activation and inflammatory signaling and may be involved in ra pathogenesis. in this study,we analyzed the expression level of a20,nf- b,and a20 regulatory factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (malt1) in patients with ra. real-time pcr was used to determine the expression level of malt1,malt-v1,a20,and nf- b genes in ra and healthy individuals (hi). significantly lower a20 expression was found in ra patients compared with those in the healthy group,while nf- b overexpression could be detected in patients with ra. moreover,the malt1 and malt1-v1 expression level was downregulated in ra patients. a positive correlation between malt1 and a20 and malt1-v1 and a20 was found in patients with ra,and a tendency towards a negative correlation was found between malt1 and nf- b,malt1-v1 and nf- b,and a20 and nf- b. in conclusion,we first characterized the alternative expression pattern of malt1,a20,and nf- b in ra,which may be related to abnormal t cell activation. © 2014 xu wang et al.
|
|
|
|
|
آدرس
|
institute of hematology,jinan university,guangzhou 510632,china,key laboratory for regenerative medicine of ministry of education,jinan university, China, institute of hematology,jinan university,guangzhou 510632,china,department of rheumatism and immunology,first hospital affiliated,jinan university, China, institute of hematology,jinan university, China, institute of hematology,jinan university, China, institute of hematology,jinan university, China, institute of hematology,jinan university, China, institute of hematology,jinan university, China, institute of hematology,jinan university, China, department of rheumatism and immunology,first hospital affiliated,jinan university, China, institute of hematology,jinan university,guangzhou 510632,china,key laboratory for regenerative medicine of ministry of education,jinan university,guangzhou 510632,china,guangdong province key laboratory of molecular immunology and antibody engineering,jinan university, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|