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Some basic aspects of HLA-G biology
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نویسنده
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alegre e. ,rizzo r. ,bortolotti d. ,fernandez-landázuri s. ,fainardi e. ,gonzález a.
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منبع
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journal of immunology research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Human leukocyte antigen-g (hla-g) is a low polymorphic nonclassical hla-i molecule restrictively expressed and with suppressive functions. hla-g gene products are quite complex,with seven hla-g isoforms,four membrane bound,and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. in addition,hla-g has been described included in exosomes. in this review we will focus on hla-g biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids. © 2014 estibaliz alegre et al.
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آدرس
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department of biochemistry,university clinic of navarra, Spain, department of medical sciences,section of microbiology and medical genetics,university of ferrara, Italy, department of medical sciences,section of microbiology and medical genetics,university of ferrara, Italy, department of biochemistry,university clinic of navarra, Spain, neuroradiology unit,sant'anna hospital, Italy, department of biochemistry,university clinic of navarra, Spain
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Authors
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