Association between the -794 (CATT)5-8 MIF gene polymorphism and susceptibility to acute coronary syndrome in a western Mexican population

The macrophage migration inhibitory factor (mif) is related to the progression of atherosclerosis,which,in turn,is a key factor in the development of acute coronary syndrome (acs). mif has a catt short tandem repeat (str) at position -794 that might be involved in its expression rate. the aim of this study was to investigate the association between the -794 catt5-8 mif gene polymorphism and susceptibility to acs in a western mexican population. this research included 200 acs patients classified according to the criteria of the american college of cardiology (acc) and 200 healthy subjects (hs). the -794 catt5-8 mif gene polymorphism was analyzed using a conventional polymerase chain reaction (pcr) technique. the 6 allele was the most frequent in both groups (acs: 54% and hs: 57%). the most common genotypes in acs patients and hs were 6/7 and 6/6,respectively,and a significant association was found between the 6/7 genotype and susceptibility to acs (68% versus 47% in acs and hs,resp.,p=0.03). we conclude that the 6/7 genotype of the mif -794 catt5-8 polymorphism is associated with susceptibility to acs in a western mexican population. © 2014 emmanuel valdés-alvarado,et al.