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HLA-G as a tolerogenic molecule in transplantation and pregnancy
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نویسنده
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rebmann v. ,da silva nardi f. ,wagner b. ,horn p.a.
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منبع
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journal of immunology research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Hla-g is a nonclassical hla class i molecule. in allogeneic situations such as pregnancy or allograft transplantation,the expression of hla-g has been related to a better acceptance of the fetus or the allograft. thus,it seems that hla-g is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. in this contribution we focus on (i) how hla-g is involved in transplantation and human reproduction,(ii) how hla-g is regulated by genetic and microenvironmental factors,and (iii) how hla-g can offer novel perspectives with respect to therapy. © 2014 vera rebmann et al.
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آدرس
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institute for transfusion medicine,university hospital essen,virchowstraße 179, Germany, institute for transfusion medicine,university hospital essen,virchowstraße 179,essen,germany,capes foundation,ministry of education of brazil,brasília, Brazil, institute for transfusion medicine,university hospital essen,virchowstraße 179, Germany, institute for transfusion medicine,university hospital essen,virchowstraße 179, Germany
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Authors
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