Cellular factors targeting APCs to modulate adaptive T cell immunity

The fate of adaptive t cell immunity is determined by multiple cellular and molecular factors,among which the cytokine milieu plays the most important role in this process. depending on the cytokines present during the initial t cell activation,t cells become effector cells that produce different effector molecules and execute adaptive immune functions. studies thus far have primarily focused on defining how these factors control t cell differentiation by targeting t cells themselves. however,other non-t cells,particularly apcs,also express receptors for the factors and are capable of responding to them. in this review,we will discuss how apcs,by responding to those cytokines,influence t cell differentiation and adaptive immunity. © 2014 anabelle visperas et al.