Activation effects of polysaccharides of flammulina velutipes mycorrhizae on the T lymphocyte immune function

Flammulina velutipes mycorrhizae have increasingly been produced with increasing of f. velutipes production. a mouse model was thus used to examine potential effect of f. velutipes mycorrhizae on the immune function. fifty female wistar mice (5-weeks-old) weighed 15-20 g were randomly allocated into five groups. polysaccharide of f. velutipes mycorrhizae were treated with mice and mice spleen lymphocytes. the levels of cd3+,cd4+,and cd8+ t lymphocyte,interleukin-2 (il-2),and tumor necrosis factor-a (tnf- α) were determined. the results showed that the proportions of cd3+,and cd4+ t lymphocyte,the ratio of cd4+/cd8+,and the levels of il-2 and tnf-a were significantly increased in polysaccharide of f. velutipes mycorrhizae,while the proportion of cd8+ t lymphocyte was decreased in polysaccharide of f. velutipes mycorrhizae-dose dependent manner. our findings indicated that a long term exposure of polysaccharide of f. velutipes mycorrhizae could activate the t lymphocyte immune function. polysaccharide of f. velutipes mycorrhizae was expected to develop into the immune health products. © 2014 zheng-fei yan et al.