|
|
|
|
HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: An updated review
|
|
|
|
|
|
|
|
نویسنده
|
cheng c.-y. ,su s.-c. ,chen c.-h. ,chen w.-l. ,deng s.-t. ,chung w.-h.
|
|
منبع
|
journal of immunology research - 2014 - دوره : 2014 - شماره : 0
|
|
چکیده
|
T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. among them,drug reaction with eosinophilia and systemic symptoms (dress) or drug-induced hypersensitivity syndrome (dihs),stevens-johnson syndrome/ toxic epidermal necrolysis (sjs/ten),are some of the most life-threatening severe cutaneous adverse reactions (scars). recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (hla) alleles and susceptibility to drug hypersensitivity. this review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between scars and specific hla alleles to avoid serious conditions associated with drug hypersensitivity. © 2014 chi-yuan cheng et al.
|
|
|
|
|
آدرس
|
department of pharmacy administration,chang gung memorial hospital, Taiwan, department of dermatology,drug hypersensitivity clinical and research center,chang gung memorial hospitals, Taiwan, department of pharmacy administration,chang gung memorial hospital, Taiwan, department of pharmacy administration,chang gung memorial hospital, Taiwan, department of pharmacy administration,chang gung memorial hospital, Taiwan, department of dermatology,drug hypersensitivity clinical and research center,chang gung memorial hospitals,linkou 33305,taiwan,college of medicine,chang gung university,taoyuan 33302,taiwan,department of dermatology,keelung chang gung memorial hospital,no. 222 maijin road,anle district, Taiwan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|