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Increased frequency of circulating follicular helper T cells in children with hand,foot,and mouth disease caused by enterovirus 71 infection
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نویسنده
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wu j. ,cui d. ,yang x. ,lou j. ,lin j. ,ye x. ,qin z. ,huang l. ,zhao d. ,huo z. ,xie g. ,zheng s. ,yu f. ,lu l. ,chen y.
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منبع
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journal of immunology research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Enterovirus 71 (ev71) is a major causative agent of hand,foot,and mouth disease (hfmd) in children. the role of t follicular helper (tfh) cells in ev71-infected children remains unclear in regulating humoral immunity. the frequency of circulating icoshigh/pd-1highcxcr5+cd4+ tfh cells in the children with mild and severe ev71 infection and healthy controls (hc) was detected by flow cytometry,respectively. il-21 and il-6 mrna expression and their serum levels,bcl-6 mrna expression,and specific neutralizing antibodies against ev71 (nab-ev71) were measured. in the acute stage of patients with ev71 infection,increased frequencies of circulating tfh cells with icoshigh and pd-1high expression in the mild and severe patients were observed,and the positive correlations among the frequencies of circulating tfh cells and the serum levels of il-21,il-6,and nab-ev71 titres were detected,respectively. moreover,the expressions of il-6 and il-21 mrna in pbmcs from patients were also significantly higher than those of hc. however,further analysis did not reveal any significant differences between mild and severe patients. these data indicate a role of tfh cells and associated cytokines in modulating the humoral response during the pathogenesis of ev71 infection. © 2014 jianping wu et al.
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آدرس
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department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,center of community health service,qingbo street, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China, department of pathology and center of infection and immunology,university of hong kong, Hong Kong, department of clinical laboratory,first affiliated hospital,zhejiang university,79 qingchun road, China
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Authors
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