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   Immunomodulation by Trypanosoma cruzi: Toward understanding the association of dendritic cells with infecting TcI and TcII populations  
   
نویسنده da costa t.a. ,silva m.v. ,mendes m.t. ,carvalho-costa t.m. ,batista l.r. ,lages-silva e. ,rodrigues v. ,oliveira c.j. ,ramirez l.e.
منبع journal of immunology research - 2014 - دوره : 2014 - شماره : 0
چکیده    Dendritic cells (dcs) are major immune components,and depending on how these cells are modulated,the protective host immune response changes drastically. trypanosoma cruzi is a parasite with high genetic variability and modulates dcs by interfering with their capacity for antigen recognition,migration,and maturation. despite recent efforts,the association between dcs and t. cruzi i (tci) and tcii populations is unknown. herein,it was demonstrated that aq1.7 and mutum tci strains present low rates of invasion of bone marrow-derived dcs,whereas the 1849 and 2369 tcii strains present higher rates. whereas the four strains similarly induced the expression of pd-l1,the production and expression of il-10 and tlr-2,respectively,in dcs were differentially increased. the production of tnf-α,il-12,il-6,and ccl2 and the expression of cd40,cd80,mhc-ii,ccr5,and ccr7 changed depending on the strain. the 2369 strain yielded the most remarkable results because greater invasion correlated with an increase in the levels of anti-inflammatory molecules il-10 and pd-l1 but not with a change in the levels of tnf-α,mhc-ii,or cd40 molecules. these results suggest that t. cruzi strains belonging to different populations have evolved specific evasion strategies that subvert dcs and consequently the host response. © 2014 thiago alvares da costa et al.
آدرس postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil, postgraduate course of tropical medicine and infectology,laboratory of immunology,federal university of triângulo mineiro,avenida getúlio guaritá s/n,uberaba, Brazil
 
     
   
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