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   Distribution of HLA-A,-B,and -C alleles and HLA/KIR combinations in han population in China  
   
نویسنده shen y. ,cao d. ,li y. ,kulski j.k. ,shi l. ,jiang h. ,ma q. ,yu j. ,zhou j. ,yao y. ,shi l.
منبع journal of immunology research - 2014 - دوره : 2014 - شماره : 0
چکیده    We investigated polymorphisms of the human leukocyte antigen (hla) class i (a,b,and c) loci of a han population (n,239) from the yunnan province,southwest china,using high-resolution polymerase chain reaction-luminex (pcr-luminex) typing. we combined the hla data from this study with the kir genotypes from a previous study of this han population to analyze the combination of kir/hla ligands. a total of 27 hla-a,54 hla-b,and 31 hla-c alleles were found in this population. the frequencies of a11:01,a24:02,b40:01,b46:01,c01:02,c03:04,and c07:02 were all > 10%. the following haplotypes were common,with frequencies > 5%: 1 a-b (a02:07-b46:01),2 a-c (a02:07-c01:02,and a11:01-c07:02),4 c-b (b13:01-c03:04,b40:01-c07:02,b46:01-c01:02 and b58:01-c03:02),and 1 a-c-b (a02:07-c01:02-b46:01). analysis of kir3d and their ligands hla-a3/a11 and hla-bw4 showed that the frequencies of 3dl2+-a3/a11+ and 3dl2+-a3/a11- were 0.527 and 0.473,and the frequencies of 3dl1+-bw4+,3dl1+-bw4-,3dl1--bw4+,and 3dl1--bw4- were 0.552,0.397,0.038,and 0.013,respectively. the results of kir/hla-c combination analysis showed that all individuals had at least one inhibitory or activating kir/hla-c pair,and one kir/hla-c pair was the most frequent (157/239),followed by two pairs (46/239),three pairs (33/239),and no pairs (3/239). comparison of kir gene and hla gene and their pair frequency between yunnan han and the isolated han (fydh) who also lived in yunnan province showed no significant difference (p>0.05) in kir frequencies,but significant differences (p<0.05) for some hla allele frequencies. in addition,there was no significant difference (p>0.05) between the two populations for kir/hla pairs. © 2014 yunsong shen et al.
آدرس first people's hosp. in yunnan prov. and the affil. hosp. of kunming sci. and technology university, China, yunnan key laboratory of vaccine research and development on severe infectious diseases,institute of medical biology,chinese academy of medical sciences (cams), China, first people's hosp. in yunnan prov. and the affil. hosp. of kunming sci. and technology university, China, centre for forensic science,university of western australia,nedlands, Australia, yunnan key laboratory of vaccine research and development on severe infectious diseases,institute of medical biology,chinese academy of medical sciences (cams), China, first people's hosp. in yunnan prov. and the affil. hosp. of kunming sci. and technology university, China, no. 3 affiliated hospital of kunming medical university, China, yunnan key laboratory of vaccine research and development on severe infectious diseases,institute of medical biology,chinese academy of medical sciences (cams), China, yunnan key laboratory of vaccine research and development on severe infectious diseases,institute of medical biology,chinese academy of medical sciences (cams), China, yunnan key laboratory of vaccine research and development on severe infectious diseases,institute of medical biology,chinese academy of medical sciences (cams), China, yunnan key laboratory of vaccine research and development on severe infectious diseases,institute of medical biology,chinese academy of medical sciences (cams), China
 
     
   
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