Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis

Psoriasis is a chronic skin disease in which genetics play a major role. although many genome-wide association studies have been performed in psoriasis,knowledge of the age at onset remains limited. therefore,we analyzed 173 single-nucleotide polymorphisms in genes associated with psoriasis and other autoimmune diseases in patients with moderate-to-severe plaque psoriasis type i (early-onset,<40 years) or type ii (late-onset,≥40 years) and healthy controls. moreover,we performed a comparison between patients with type i psoriasis and patients with type ii psoriasis. our comparison of a stratified population with type i psoriasis n = 155 and healthy controls n = 197 is the first to reveal a relationship between the clmn,fbxl19,ccl4l,c17orf51,tyk2,il13,slc22a4,cdkal1,and hla-b/mica genes. when we compared type i psoriasis with type ii psoriasis n = 36,we found a significant association between age at onset and the genes psors6,tnf,fcgr2a,tnfr1,cd226,hla-c,tnfaip3,and cchcr1. moreover,we replicated the association between rs12191877 (hla-c) and type i psoriasis and between type i and type ii psoriasis. our findings highlight the role of genetics in age of onset of psoriasis. © 2015 rocío prieto-pérez et al.