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Harnessing the Microbiome to Enhance Cancer Immunotherapy
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نویسنده
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nelson m.h. ,diven m.a. ,huff l.w. ,paulos c.m.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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The microbiota plays a key role in regulating the innate and adaptive immune system. herein,we review the immunological aspects of the microbiota in tumor immunity in mice and man,with a focus on toll-like receptor (tlr) agonists,vaccines,checkpoint modulators,chemotherapy,and adoptive t cell transfer (act) therapies. we propose innovative treatments that may safely harness the microbiota to enhance t cell-based therapies in cancer patients. finally,we highlight recent developments in tumor immunotherapy,particularly novel ways to modulate the microbiome and memory t cell responses to human malignancies. © 2015 michelle h. nelson et al.
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آدرس
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department of microbiology and immunology,medical university of south carolina,charleston,sc,united states,department of surgery,medical university of south carolina,charleston, United States, department of microbiology and immunology,medical university of south carolina,charleston, United States, department of microbiology and immunology,medical university of south carolina,charleston,sc,united states,department of surgery,medical university of south carolina,charleston, United States, department of microbiology and immunology,medical university of south carolina,charleston,sc,united states,department of surgery,medical university of south carolina,charleston, United States
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Authors
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