HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling

The human t-cell lymphotropic virus type 1 (htlv-1) is a retrovirus associated with both proliferative and inflammatory disorders. this virus causes a persistent infection,mainly in cd4+ t lymphocyte. the ability to persist in the host is associated with the virus capacity to evade the immune response and to induce infected t-cell proliferation,once the htlv-1 maintains the infection mainly by clonal expansion of infected cells. there are several evidences that orf-i encoded proteins,such as p12 and p8,play an important role in this context. the present study will review the molecular mechanisms that htlv-1 orf-i encoded proteins have to induce dysregulation of intracellular signaling,in order to escape from immune response and to increase the infected t-cell proliferation rate. the work will also address the impact of orf-i mutations on the human host and perspectives in this study field. © 2015 carolina rosadas and marzia puccioni-sohler.