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Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque
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نویسنده
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zhang g.-h. ,wu r.-d. ,zheng h.-y. ,zhang x.-l. ,zhang m.-x. ,tian r.-r. ,liu g.-m. ,pang w. ,zheng y.-t.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Immune activation plays a significant role in the disease progression of hiv. microbial products,especially bacterial lipopolysaccharide (lps),contribute to immune activation. increasing evidence indicates that t lymphocyte homeostasis disruptions are associated with immune activation. however,the mechanism by which lps affects disruption of immune response is still not fully understood. chronically shivb'whu-infected chinese rhesus macaques received 50 μg/kg body weight lps in this study. lps administration affected the virus/host equilibrium by elevating the levels of viral replication and activating t lymphocytes. lps induced upregulation of cd8+ naïve t cells and downregulated the number of cd4+ and cd8+ t effector memory cells. the downregulated effector memory cells are associated with a lower frequency of monofunctional and polyfunctional cells,and an upregulated programmed cell death-1 (pd-1) expression on cd4+ and cd8+ t cells was observed in monkeys after lps stimulation. our data provide new insights into the function of lps in the immune activation in shiv/hiv infection. © 2015 gao-hong zhang et al.
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آدرس
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key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming, China, key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming,yunnan,china,college of pharmacy and chemistry,dali university,dali, China, key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming,yunnan,china,school of life sciences,university of science and technology of china,hefei, China, key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming, China, key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming,yunnan,china,university of chinese academy of sciences, China, key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming,yunnan,china,university of chinese academy of sciences, China, college of pharmacy and chemistry,dali university,dali, China, key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming, China, key laboratory of animal models and human disease mechanisms,chinese academy of sciences and yunnan province,kunming institute of zoology,chinese academy of sciences,kunming, China
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Authors
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