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   Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile  
   
نویسنده diáz a. ,santucci n. ,bongiovanni b. ,d'attilio l. ,massoni c. ,lioi s. ,radcliffe s. ,dídoli g. ,bottasso o. ,bay m.l.
منبع journal of immunology research - 2015 - دوره : 2015 - شماره : 0
چکیده    Tuberculosis (tb) is a major health problem requiring an appropriate cell immune response (ir) to be controlled. since regulatory t cells (tregs) are relevant in ir regulation,we analyzed tregs variations throughout the course of tb treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. the cohort was composed of 41 adult patients,20 of them completing treatment and follow-up. patients were bled at diagnosis (t0) and at 2 (t2),4 (t4),6 (t6),and 9 months following treatment initiation. twenty-four age-and sex-matched healthy controls (hco) were also included. tregs (flow cytometry) from tb patients were increased at t0 (versus hco p<0.05),showing even higher values at t2 (versus t0 p<0.01) and t4 (versus t0 p<0.001). while il-6,ifn-γ,tgf-β (elisa),and cortisol (electrochemiluminescence,eq) were augmented,dhea-s (eq) levels were diminished at t0 with respect to hco,with cytokines and cortisol returning to normal values at t9. tregs correlated positively with ifn-γ (r=0.868,p<0.05) at t2 and negatively at t4 (r=-0.795,p<0.05). lowered levels of proinflammatory cytokines together with an increased frequency of tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation. © 2015 ariana diáz et al.
آدرس institute of immunology,school of medical sciences,national university of rosario,rosario, Argentina, institute of immunology,school of medical sciences,national university of rosario,rosario, Argentina, institute of immunology,school of medical sciences,national university of rosario,rosario, Argentina, institute of immunology,school of medical sciences,national university of rosario,rosario, Argentina, central laboratory,centenary provincial hospital,rosario, Argentina, central laboratory,centenary provincial hospital,rosario, Argentina, central laboratory,centenary provincial hospital,rosario, Argentina, institute of immunology,school of medical sciences,national university of rosario,rosario, Argentina, institute of immunology,school of medical sciences,national university of rosario,rosario, Argentina, institute of immunology,school of medical sciences,national university of rosario,rosario, Argentina
 
     
   
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