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Treatment of Bullous Systemic Lupus Erythematosus
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نویسنده
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duan l. ,chen l. ,zhong s. ,wang y. ,huang y. ,he y. ,chen j. ,shi g.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Bullous systemic lupus erythematosus (bsle) is an autoantibody-mediated vesiculobullous disease in patients with sle. autoimmunity in bsle is characterized by the presence of circulating anti-type vii collagen antibodies. bsle patients often present with multiple,tense,clear fluid-filled vesicles and bullae overlying erythematous edematous plaques. skin biopsy from bsle patients shows subepidermal bullae with numerous neutrophils and only occasional eosinophils. furthermore,immunofluorescence examination showed linear deposition of lgg,lga,c3,and c1q along the basement membrane zone. bsle patients with corticosteroids treatment constantly do not receive a marked improvement,while dapsone generally dramatically improved the skin condition. recently,it has been reported that quite a few cases of bsle were successfully treated with other immune suppressive drugs. therefore,a comprehensive review of the treatment of bsle would be beneficial to cure the disease. copyright © 2015 lihua duan et al.
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آدرس
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department of rheumatology and clinical immunology,xiamen university, China, department of rheumatology and clinical immunology,xiamen university, China, department of pathology,xiamen university, China, department of rheumatology and clinical immunology,xiamen university, China, department of rheumatology and clinical immunology,xiamen university, China, department of rheumatology and clinical immunology,xiamen university, China, department of immunology,college of medicine,xiamen university, China, department of rheumatology and clinical immunology,xiamen university, China
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Authors
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