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IL-34 suppresses candida albicans induced tnf α production in m1 macrophages by downregulating expression of dectin-1 and tlr-2
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نویسنده
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xu r. ,sun h.-f. ,williams d.w. ,jones a.v. ,al-hussaini a. ,song b. ,wei x.-q.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Candida albicans is a fungus that is an opportunistic pathogen of humans. normally,c. albicans exists as a harmless commensal and does not trigger inflammatory responses by resident macrophages in skin mucosa,which may be caused by a tolerance of skin macrophage to c. albicans. il-34 is a recently discovered cytokine,constitutively expressed by keratinocytes in the skin. il-34 binds to the receptor of m-csf,thereby stimulating tissue macrophage maturation and differentiation. resident macrophages exhibit phenotypic plasticity and may transform into inflammatory m1 macrophages for immunity or anti-inflammatory m2 macrophages for tissue repair. m1 macrophages produce higher levels of inflammatory cytokines such as tnfα in response to c. albicans stimulation. in this study,it was demonstrated that il-34 attenuated tnfα production by m1 macrophages challenged with heat killed candida (hkc). the molecular mechanism of il-34 mediated suppression of hkc induced tnfα production by m1 macrophages was by the inhibition of m1 macrophage expression of key c. albicans pattern recognition receptors (pprs),namely,toll-like receptor (tlr) 2 and dectin-1. the results of this study indicated that constitutive il-34 expressed by skin keratinocytes might suppress resident macrophage responses to c. albicans colonisation by maintaining low levels tlr2 and dectin-1 expression by macrophages. © 2015 rong xu et al.
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آدرس
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tissue engineering and reparative dentistry,school of dentistry,cardiff university,heath park,cardiff cf14 4xy,united kingdom,tianjin key laboratory of biomaterial research,institute of biomedical engineering,chinese academy of medical science, China, tianjin key laboratory of biomaterial research,institute of biomedical engineering,chinese academy of medical science, China, tissue engineering and reparative dentistry,school of dentistry,cardiff university,heath park, United Kingdom, tissue engineering and reparative dentistry,school of dentistry,cardiff university,heath park, United Kingdom, tissue engineering and reparative dentistry,school of dentistry,cardiff university,heath park, United Kingdom, tissue engineering and reparative dentistry,school of dentistry,cardiff university,heath park, United Kingdom, tissue engineering and reparative dentistry,school of dentistry,cardiff university,heath park, United Kingdom
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Authors
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