Anti-Phosphatidylserine/Prothrombin Antibodies Are Associated with Adverse Pregnancy Outcomes

Objective. to determine the prevalence and clinical association of anti-phosphatidylserine/prothrombin antibodies (aps/pt) in patients with a history of pregnancy complications relevant to antiphospholipid syndrome (aps). materials and methods. two hundred and eleven patients with a history of (a) three or more consecutive miscarriages before 10th week of gestation (wg) (n = 64),(b) death of a morphologically normal fetus beyond 10th wg (n = 72),(c) premature birth of a morphologically normal neonate before 34th wg due to eclampsia,preeclamsia and placental insufficiency (n = 33),and (d) less than three unexplained consecutive miscarriages before 10th wg (n = 42). subjects sera were analyzed for lupus anticoagulant (la),anti-cardiolipin (acl),anti-β2 -glycoprotein i (anti-β2 gpi),and aps/pt antibodies. results. 41/169 (24.3%) of patients were positive for at least one measured apl. the highest prevalence was found for aps/pt and acl (13.0% and 12.4%,resp.) followed by la (7.7%) and anti-β2 gpi (7.1%). 11/169 with aps-related obstetric manifestations had only aps/pt. 17.8% of patients were positive for la or acl and/or anti-β2 gpi; however when adding the aps/pt results,an additional 7% of patients could be evaluated for aps. conclusion. aps/pt are associated with recurrent early or late abortions and with premature delivery irrespective of other apl. copyright © 2015 polona žigon et al.