Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis

Although there is no evidence for a role of anti-mog antibodies in adult ms,no information on b lymphocytes with mog-committed bcr is available. we report here on the frequency of anti-mog b cells forming rosettes with polystyrene beads (bbr) covalently bound to the extracellular domain of rhmog in 38 relapsing-remitting patients (rrms) and 50 healthy individuals (hi). we show a substantial proportion of circulating anti-mog-bbr in both rrms and hi. strikingly,mog-specific b cells frequencies were lower in ms than in hi. anti-mog antibodies measured by a cell-based assay were not different between ms patients and controls,suggesting a specific alteration of anti-mog b cells in ms. although anti-mog-bbr were higher in cns fluid than in blood,no difference was observed between ms and controls. lower frequency of mog-bbr in ms was not explained by an increased apoptosis,but a trend for lower proliferative capacity was noted. despite an efficient b cell transmigration across brain derived endothelial cells,total and anti-mog b cells transmigration was similar between ms and hi. the striking alteration in mog-specific b cells,independent of anti-mog antibody titers,challenges our view on the role of mog-specific b cells in ms. copyright © 2015 annie elong ngono et al.