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Mesenchymal Stem Cells Immunosuppressed IL-22 in Patients with Immune Thrombocytopenia via Soluble Cellular Factors
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نویسنده
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wu m. ,ge h. ,li s. ,chu h. ,yang s. ,sun x. ,zhou z. ,zhu x.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Mesenchymal stem cells are immunoregulation cells. il-22 plays an important role in the pathogenesis of immune thrombocytopenia. however,the effects of mesenchymal stem cells on il-22 production in patients with immune thrombocytopenia remain unclear. flow cytometry analyzed immunophenotypes of mesenchymal stem cells; differentiation of mesenchymal stem cells was observed by oil red o and alizarin red s staining; cell proliferation suppression was measured with mts; il-22 levels of cell-free supernatants were determined by elisa. mesenchymal stem cells inhibited the proliferation of activated cd4+t cells; moreover,mesenchymal stem cells immunosuppressed il-22 by soluble cellular factors but not pge2. these results suggest that mesenchymal stem cells may be a therapeutic strategy for patients with immune thrombocytopenia. © 2015 mei wu et al.
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آدرس
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department of hematology,people's hospital of bozhou, China, department of hematology,people's hospital of bozhou, China, department of hematology,people's hospital of bozhou, China, department of hematology,people's hospital of bozhou, China, department of hematology,people's hospital of bozhou, China, department of hematology,people's hospital of bozhou, China, department of hematology,people's hospital of bozhou, China, department of hematology,first hospital of quanzhou affiliated to fujian medical university, China
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Authors
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