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Evaluation of anti-TBGL antibody in the diagnosis of tuberculosis patients in China
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نویسنده
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zhao j. ,zhu z. ,zhang x. ,suzuki y. ,chagan-yasutan h. ,chen h. ,wan y. ,xu j. ,ashino y. ,hattori t.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Tuberculous glycolipid (tbgl) is a component of the mycobacterium tuberculosis cell wall,and anti-tbgl antibodies are used for serodiagnosis of tuberculosis. anti-tbgl igg and iga levels were measured in 45 pulmonary tb patients (ptb),26 extra-pulmonary tb patients (etb),16 aids-tb patients,and 58 healthy controls (hc) including 39 health care workers (hw) and 19 newly enrolled students (st). anti-tbgl igg measurements yielded 68.9% and 46.2% sensitivity in ptb and etb,respectively,and 81.0% specificity. however,anti-tbgl iga measurements were significantly less sensitive in detecting etb than ptb (15.4% versus 46.7% sensitivity) but showed up to 89.7% specificity. samples from aids-tb patients exhibited low reaction of anti-tbgl igg and iga with 6.3% and 12.5% sensitivity,respectively. unlike anti-lipoarabinomannan (lam) igg that was found to elevate in sputum smearpositive subjects,anti-tbgl igg and iga elevated in those with cavitation and bronchiectasis,respectively. anti-tbgl igg in cavitary tb yielded 78.2% sensitivity compared to 57.1% in those otherwise. meanwhile,higher anti-tbgl iga titers were observed in hw than in st,and increasing anti-tbgl igg titers were observed in hw on follow-up. therefore,higher anti-tbgl antibody titers are present in patients presenting cavities and bronchiectasis and subjects under tb exposure risk. © 2015 jingge zhao et al.
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آدرس
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division of emerging infectious diseases,department of internal medicine,tohoku university,sendai, Japan, shanghai public health clinical center,fudan university, China, shanghai public health clinical center,fudan university,shanghai,china,key laboratory of medical molecular virology of the ministries of education,school of basic medical science,fudan university, China, division of global epidemiology,hokkaido university research center for zoonosis control,sapporo, Japan, division of emerging infectious diseases,department of internal medicine,tohoku university,sendai,miyagi,japan,laboratory of disaster-related infectious disease,international research institute of disaster science,tohoku university,sendai, Japan, shanghai public health clinical center,fudan university, China, shanghai public health clinical center,fudan university,shanghai,china,key laboratory of medical molecular virology of the ministries of education,school of basic medical science,fudan university, China, shanghai public health clinical center,fudan university,shanghai,china,key laboratory of medical molecular virology of the ministries of education,school of basic medical science,fudan university, China, division of emerging infectious diseases,department of internal medicine,tohoku university,sendai, Japan, division of emerging infectious diseases,department of internal medicine,tohoku university,sendai,miyagi,japan,laboratory of disaster-related infectious disease,international research institute of disaster science,tohoku university,sendai, Japan
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Authors
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