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   Immunomodulatory effects mediated by serotonin  
   
نویسنده arreola r. ,becerril-villanueva e. ,cruz-fuentes c. ,velasco-velázquez m.a. ,garces-alvarez m.e. ,hurtado-alvarado g. ,quintero-fabian s. ,pavon l.
منبع journal of immunology research - 2015 - دوره : 2015 - شماره : 0
چکیده    Serotonin (5-ht) induces concentration-dependent metabolic effects in diverse cell types,including neurons,entherochromaffin cells,adipocytes,pancreatic beta-cells,fibroblasts,smooth muscle cells,epithelial cells,and leukocytes. three classes of genes regulating 5-ht function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-ht,such as sert,5htr-gpcr,and the 5htion channels; (b) downstream signaling transduction proteins; and (c) enzymes controlling 5-ht metabolism,such as ido and mao,which can generate biologically active catabolites,including melatonin,kynurenines,and kynurenamines. this review covers the clinical and experimental mechanisms involved in 5-ht-induced immunomodulation. these mechanisms are cell-specific and depend on the expression of serotonergic components in immune cells. consequently,5-ht can modulate several immunological events,such as chemotaxis,leukocyte activation,proliferation,cytokine secretion,anergy,and apoptosis. the effects of 5-ht on immune cells may be relevant in the clinical outcome of pathologies with an inflammatory component. major depression,fibromyalgia,alzheimer disease,psoriasis,arthritis,allergies,and asthma are all associated with changes in the serotonergic system associated with leukocytes. thus,pharmacological regulation of the serotonergic system may modulate immune function and provide therapeutic alternatives for these diseases. © 2015 rodrigo arreola et al.
آدرس psychiatric genetics department,clinical research branch,national institute of psychiatry,calzada mexico-xochimilco 101, Mexico, department of psychoimmunology,national institute of psychiatry,ramón de la fuente,calzada méxico-xochimilco 101, Mexico, psychiatric genetics department,clinical research branch,national institute of psychiatry,calzada mexico-xochimilco 101, Mexico, school of medicine,national autonomous university of mexico,avenida universidad 3000, Mexico, department of psychoimmunology,national institute of psychiatry,ramón de la fuente,calzada méxico-xochimilco 101, Mexico, area of neurosciences,department of biology of reproduction,universidad autonoma metropolitana,avenida san rafael atlixco no. 186, Mexico, genetics unit nutrition of biomedical research,universidad nacional autonoma de mexico,instituto nacional de pediatriá,avenida del iman no. 1, Mexico, department of psychoimmunology,national institute of psychiatry,ramón de la fuente,calzada méxico-xochimilco 101, Mexico
 
     
   
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