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Low baseline interleukin-17A levels are associated with better treatment response at 12 weeks to tocilizumab therapy in rheumatoid arthritis patients
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نویسنده
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lee s.j. ,park w. ,park s.h. ,shim s.-c. ,baek h.j. ,yoo d.-h. ,kim h.a. ,lee s.k. ,leee y.j. ,park y.e. ,cha h.-s. ,park j.k. ,lee e.y. ,lee e.b. ,song y.w.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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T helper 17-related cytokines have been implicated in rheumatoid arthritis (ra) pathogenesis. the study aimed to identify cytokines associated with the treatment response of ra patients to tocilizumab (tcz),a humanized monoclonal antibody against the interleukin- (il-) 6 receptor. as an independent substudy of the 24-week,randomized,double-blinded cwp-tcz301 trial of tcz in ra patients with an inadequate response to disease-modifying antirheumatic drugs,serum levels of cytokines including tumor necrosis factor-alpha,il-17a,il-21,il-23,il-6,and soluble il-6 receptor were measured. baseline il-17a levels were significantly lower in ra patients who achieved disease activity score 28 (das28) remission at 12 weeks of tcz treatment,compared to patients not in remission. patients were stratified into il-17a low group and il-17a high group. significantly more patients in the il-17a low group achieved remission as compared to the il-17a high group (47.6 versus 17.4%,p=0.032). das28 improvement was significantly better in the il-17a low group than in the il-17a high group at 12 weeks (p=0.045) and 24 weeks (p=0.046) after adjustment. other baseline cytokines were not associated with treatment response to tcz. the data demonstrate that low baseline il-17a levels are associated with better clinical response to tcz treatment in ra patients. copyright © 2015 sang jin lee et al.
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آدرس
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division of rheumatology,seoul national university hospital,seoul,south korea,department of molecular medicine and biopharmaceutical sciences,graduate school of convergence science and technology and college of medicine,seoul national university, South Korea, division of rheumatology,inha university hospital, South Korea, division of rheumatology,catholic university,korea seoul st. mary's hospital, South Korea, division of rheumatology,eulji university hospital, South Korea, division of rheumatology,gachon university gil medical center, South Korea, division of rheumatology,hanyang university medical center, South Korea, division of rheumatology,hallym university medical center, South Korea, division of rheumatology,yonsei university health system, South Korea, division of rheumatology,seoul national university bundang hospital, South Korea, division of rheumatology,pusan national university hospital, South Korea, division of rheumatology,samsung medical center, South Korea, division of rheumatology,seoul national university hospital,seoul,south korea,department of molecular medicine and biopharmaceutical sciences,graduate school of convergence science and technology and college of medicine,seoul national university, South Korea, division of rheumatology,seoul national university hospital, South Korea, division of rheumatology,seoul national university hospital, South Korea, division of rheumatology,seoul national university hospital,seoul,south korea,department of molecular medicine and biopharmaceutical sciences,graduate school of convergence science and technology and college of medicine,seoul national university, South Korea
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Authors
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