Balancing innate immunity and inflammatory state via modulation of neutrophil function: A novel strategy to fight sepsis

Sepsis and sirs (systemic inflammatory response syndrome) belong to a severe disease complex characterized by infection and/or a whole-body inflammatory state. there is a growing body of evidence that neutrophils are actively involved in sepsis and are responsible for both release of cytokines and phagocytosis of pathogens. the neutrophil level is mainly regulated by g-csf,a cytokine and drug,which is widely used in the septic patient with neutropenia. this review will briefly summarize the role of neutrophils and the therapeutic effect of g-csf in sepsis. we further suggest that targeting neutrophil function to modulate the balance between innate immunity and inflammatory injury could be a worthwhile therapeutic strategy for sepsis. © 2015 haoshu fang et al.